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5.3 Overcoming the bloodbrain barrier (BBB): nanocarrier-based drug delivery The BBB severely restricts CNS penetration of most therapeutic agents

The consequent three-dimensional structure, stability and dynamic behavior of such protein regions are all tightly linked to the process of aggregation 47,48,49,50,51

Short- or long-term high-fat diet feeding plus acute ethanol binge synergistically induce acute liver injury in mice: an important role for CXCL1

Notably, oncogenic mutations in Hras, Kras, and Nras, are common in approximately 25% of human cancers, and Kras mutations have been identified in 86% of Ras-driven cancers, including about 98% of pancreatic and 53% of colorectal cancers 44