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Symptoms such as fatigue, irritability, and slowed thinking often develop gradually and may be mistaken for stress or aging

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Participants in the trial received weekly Li-ESWT treatments for three weeks, followed by a PRP injection on the same day as the last shockwave treatment

Notably, NNMT inhibition did not impact food intake in the DIO mice nor produce any overt signs of toxicity or adverse behavioral effects at the pharmacologically effective dose