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Impaired mitochondria not only generate excess ROS but also compromise cellular antioxidant capacity, compounding the overall oxidative stress [64]

The Se derivatives are characterized by various levels of toxicity

However, ZD was observed in the hippocampus and cortex of the R6/1 mouse model of HD

(2018), neurodegeneration-associated molecular patterns (NAMPs) was proposed as endogenous danger signals commonly present in various CNS conditions, which are recognized by a battery of specific receptors constitutively expressed on microglia and trigger their transition into DAM (Figure 3, Table 1), whose primary function is to contain and remove the damage