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Due to the formidable barrier posed by the SC, only a limited number of drugs are approved for transdermal delivery [228, 229]

Lim CL, Mackinnon LT

Some individuals may experience mild discomfort, swelling or redness at the injection site

and Type V, although less common, is characterized by fat distribution predominantly in the calves Notably, some literature also describes involvement of the lower abdomen, especially in Types I and II, although this is not consistently reflected across all classification systems.8,15,21,22 Regarding morphological appearance, lipedema progresses through four clinical stages (Table 2): Stage I is characterized by smooth skin with thickened but soft subcutaneous tissue containing small nodules