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2 Computational details The CASSCF(14,13) geometry optimization of cyanocobalamin, aquacobalamin, Methylcobalamin was studied alongside glutathione, flavin, or flavin-related agents (see Fig

Minor criteria include spontaneous and/or easy bruising demonstrating tissue fragility, thin translucent skin, and early-onset varicose veins, as well as other nondermatological features

The model describes a positive feedback (more cytotoxicity releases more auto-antigens) and a negative one (cytotoxicity stimulates immunoregulatory T Reg )