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SJS lesions contained lower concentrations of granulysin compared to TEN lesions, which could explain the differences of clinical severity in these pathologically identical conditions

Indeed this finding is similar to studies of ischaemic damage in the brain which show MG-mediated protection occurs in the presence of similar cytokines that we show are elevated here in the ischaemic retina, including sICAM, INF, IL-1, KC(CXCL1), MCP-5 (CCL12), MIP2(CXCL2) and TNF 57

The detailed analysis of the differences in the sample size, in the number of RCTs included for each outcome, and in the results between the present study and the Cochrane meta-analysis is detailed in Table 3