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(III.2.F) EXVIVO STUDY Ex vivo study on goat sublingual mucosa shows increase in permeation of drug through mucosa than that of In vitro condition because chitosan is able to break tight junction hence facilitate the passage of drug through this route .On the other hand PG will increase the pore size of the membrane along with alcohol as a result increase in Para-cellular movement of the drug .Therefore Ex- vivo data will help to predict In- vivo permeation pattern of the formulation

These findings suggest that GSSG may act as a neuromodulator that is capable of warning naive animals to anticipate unfavorable future events, such as encounters with a pathogen, and inducing aversive learning toward the pathogen

Out of a total of 554 cases (227 children) with CD, 48% of adults and 8% of children had IDA at the time of diagnosis

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