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These results are attributed to the maintenance of metabolic homeostasis in cancer cells by phosphoglycerate dehydrogenase (PHGDH)-mediated serine biosynthesis cysteine catabolism, which are upregulated in a variety of cancers, including esophageal, lung and liver cancers, and are associated with cell proliferation, metastasis, and chemoresistance [57,58,59]

PPARs use their ligand-binding domains to bind to these ligands

These findings support the further investigation of glutamine-coupled organophilin (IV) compounds as potential chemotherapeutic agents for the treatment of colon cancer [186]