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However, GSSG levels did not change substantially with aging in most of the 10 brain regions measured but declined significantly between 15 and 23 months of age in the brainstem, thalamus, and hypothalamus, while taurine levels also declined slightly ( C57BL/6J male mice showed a mean lifespan roughly 8% longer than C57BL/6N males, while C57BL/6J female mice showed a mean lifespan roughly 5% longer than C57BL/6N females (Ogiso et al., 2025)

The purine targeted by hydroxyl radical generates various purine adducts like 2,6-diamino-4-hydroxy-5-formamidopyrimidine, 8-hydroxy deoxy adenosine, and 8-hydroxydeoxy guanosine