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In 2019 the projected number of incidents and prevalent strokes were 12.22 million (70% increment from 1990) and 101.47 million (85% increment from 1990), respectively [1]

Since GLP-1 receptors exist throughout the gastrointestinal system and central nervous system, activation of these receptors produces the therapeutic benefits of appetite suppression and glucose regulation but also accounts for the predominant gastrointestinal side effects experienced by many users

Reassuringly, such adverse events appear rare: among 1.2 million injections, 79 cases of anaphylaxis were reported, with most neither severe nor fatal, and moderate side effects observed in only 0.2% of cases [47]

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