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This represents an open and potentially productive area for future investigation

This strategy is mainly achieved through the following methods: First, by using techniques like photodynamic therapy (PDT), a large amount of ROS is generated locally in the tumor via nanocarriers, inducing ICD in tumor cells

Although the mechanism is not clear, research in animals suggests that riboflavin deficiency may impair iron absorption, increase intestinal loss of iron, and/or impair iron utilization for the synthesis of hemoglobin (16)

Since NAD + is required for ATP production, FK866-induced NAMPT inhibition affects ATP production and, consequently, results in AMPK activation (in hepatocarcinoma cells)