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Sixteen weeks of running wheel exercise upregulate the expression of adiponectinreceptor1 (AdipoR1) protein in the skeletal muscle of aged mice, promotes its downstream proteins transcriptional activity, forkhead box class O3 (FOXO3) to increase FOXO3a protein levels, which in turn upregulates LC3-II and BNIP3 protein expression, downregulates p62/SQSTM1 protein levels, and increases the mRNA expressions of Beclin1, ULK1, recombinant phosphoinositide-3-kinase class 3 (Pik3c3), ATG5, ATG7, LC3B, BNIP3, and PINK1

Ocul Immunol Inflam

84 Exosynaptic glutamate also contributes to metabolism in neurons and astrocytes