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Most studies involved arbitrary substitutions of some amount of T3 for some amount of the patients usual T4 dose, without regard for the patients symptoms or serum FT4 and FT3 levels

Between 1975 and 1999, approximately 10% of the drugs launched in the market were given a black-box warning by the FDA or were taken off the market due to reported incidences of IDRs (26)

Milani C, Duranti S, Bottacini F, Casey E, Turroni F, Mahony J, Belzer C, Delgado Palacio S, Arboleya Montes S, Mancabelli L, Lugli GA, Rodriguez JM, Bode L, de Vos W, Gueimonde M, Margolles A, van Sinderen D, Ventura M (2017) The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

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