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The rest is simply excreted

Wu D, Feng Y, Wang R et al (2023) Pigment microparticles and microplastics found in human thrombi based on Raman spectral evidence

The ZIPs are typically synthesized on ribosomes attached to the endoplasmic reticulum (ER) and later transported to various intracellular compartments

Unlike -KG, abnormal accumulation of succinate and fumarate in tumor tissues represses PHD, thus reducing HIF1 hydrolysis, suppressing demethylation of DNA and histones, and promoting the occurrence and development of tumors (Cavalli and Heard, 2009