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In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)

(2002) Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz

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In addition, defense of the intestinal barrier can also prevent the occurrence of a variety of diseases, such as inflammatory bowel disease (IBD) [15], liver diseases [16], Alzheimers disease [17], type 2 diabetes [18], and cardiovascular diseases [19, 20], which are related to dysfunction of the intestinal barrier