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Intracellular IGF-1 is mainly expressed as proIGF-1Ea, not mature IGF-1 Using RT-PCR analyses, we previously demonstrated that skeletal muscles, adipose tissues and liver of several mammalian species mainly expressed the IGF-1Ea isoform, which represents about 90% of IGF-1 transcripts 5

The proliferation of pancreatic connective tissue and severe blood supply deficiency results in local tumor cells being exposed to a microenvironment of nutrient deprivation, hypoxia, and high oxidative stress

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These strategies not only illustrate the depth and breadth of pharmaceutical research but also signify the frontier of future medical innovations