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Acetyl-CoA and NADPH generated from glycolysis directly fuel DNL, representing a primary metabolic link between glucose and lipid pathways

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Relationship between brain lipid metabolism and senescence The role of lipids in the brain Lipids constitute approximately 60% of the brain's dry mass, with a marked concentration within neuronal membranes and the myelin sheath, which functions as a critical insulator for axonal conduction

Visceral hypersensitivity, serotonin dysregulation, gut-brain axis dysfunction, and central/peripheral nervous system alterations are implicated in IBS-C pain, while FC pain is less studied and may be primarily linked to colonic distension and motility dysfunction