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In 1958, the first synthetic T4 entered the market: Synthroid, originally manufactured by Flint Laboratories

10.1186/s13018-019-1242-6 54 PetrovicI.DobricI.DrmicD.SeverM.KlicekR.RadicB.et al (2011)

Foods that support microbiome diversity include: Vegetables Whole grains Legumes Fruits rich in polyphenols Fermented Foods Fermented foods introduce beneficial microbes that may help support microbiome diversity