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Notably, supplementing NADPH and using a pharmacological inhibitor of aldose reductase an enzyme using NADPH oxidase for the formation of sorbitol in high-glucose conditions - successfully restored the sensitivity to LPS-induced NET formation in high glucose conditions, while reducing high glucose-induced cytosolic ROS production, neutrophil elastase secretion and spontaneous NET release (Table 4)

(1) To assess myelin sparing, tissue sections were stained with Luxol Fast Blue (LFB) as described [25]

Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis

Materials and methods Experimental animals and design One day before the start of this study, the suckling piglets were selected from a total of 101 animals, originating from eight different litters at a commercial farm