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A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats

32,33 In a small 3-week randomized crossover placebo-controlled study, treatment with subcutaneous ketamine 80 mg in the outpatient setting provided acute pain relief and decreased frequency of attacks

Xie et al, 2017

PNC-27 is derived from the p53 proteins HDM-2 binding domain (amino acids 12-26) and is linked to a membrane-penetrating sequence, allowing it to enter and act on cancer cell membranes