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Key Findings: Asian participants: 21.3% mean weight loss with CagriSema (similar to overall population) Safety profile consistent across ethnicities GI tolerability similar but potentially lower discontinuation rates in Asian populations Clinical Significance: Supports global applicability of cagrilintide-based therapies across diverse populations

The most clinically relevant efficacy data came from METAOD005, a 12-week randomized double-blind placebo-controlled study

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Mov Disord 26:558559 Santos-Garca D et al (2012) Polyneuropathy while on duodenal levodopa infusion in Parkinsons disease patients: we must be alert