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Chemokines such as CCL2, CCL18, and CXCL12 are instrumental in promoting either a pro-inflammatory M1 phenotype, which is associated with pathogen clearance and tissue damage, or an anti-inflammatory M2 phenotype, which is involved in tissue repair, fibrosis, and tumor progression (65)

It is the constant flux between the two GSH species that allows for the continuous clearing of ROS

194 This result was consistent with the accumulation of CSA in patient-derived low-grade glioma and with the intra-tumoural expression of CDO1, 76 since the decreased level of cysteine can be due to the overexpression and activity of CDO1 found in high-grade glioblastomas

3533-C DETERMINANTS OF RISKS ASSOCIATED WITH ALCOHOL-ASSOCIATED HEPATITIS: A COMPREHENSIVE ANALYSIS OF THE ALL OF US COHORT Chenxi Xiong 1 , Xiang Liu 1 , Wanzhu Tu 1 , Suthat Liangpunsakul 2,3 and Jing Su 1 , (1)Department of Biostatistics and Health Data, Indiana University School of Medicine, Indianapolis, in, (2)Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, (3)Roudebush Veterans Administration Medical Center, Indianapolis, in Background: Alcohol-associated hepatitis (AH) is a severe adverse health outcome associated with alcohol use disorder (AUD)