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Furthermore, OS and cytokines played a silent key role in mediating the progression of NAFLD from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis which further prompts cardiovascular ill effects or coronary heart disease

Ni M, Li X, Yin Z, Jiang H, Sidoryk-Wgrzynowicz M, Milatovi D, Cai J, Aschner M (2010) Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells

Although nanotechnology-based delivery systems have been explored to address these challenges, the current literature lacks mechanistic integration and critical comparison of nanoformulation strategies