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SKU: 74177571911
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Availability: InStock
Rating: 4.3888 (29 reviews)

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SKU: 74177571911 · From chapuisstores.ch

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Description

Tricellulin deficiency affects tight junction architecture and cochlear hair cells

39,40,41,42 This process requires an active escort mechanism, whereby the AAA+ ATPase p97/valosin-containing protein (VCP) (known as Cdc48 in yeasts) extracts misfolded, damaged, or improperly synthesized proteins from the ER to enable their recognition and processing by ER-dedicated E3 ubiquitin ligases, which mark them for degradation by the 26S proteasome