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Lancet Psychiatry 2021, 8 (5), 416427

Buffett-Jerrott SE, Stewart SH

As a benzothiazole drug, the drug operates on a foundation of neuronal protection, blocking voltage-gated sodium channels to reduce the release of the excitatory neurotransmitter glutamate and increasing glutamate uptake through excitatory amino acid transporter to regulate extracellular glutamate levels (21)

A successful strategy will be inherently multidisciplinary, synergizing advances in microbiology, immunology, computational biology, and clinical medicine