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Among these, erastin (named for er adicator of RAS and ST -expressing cells) was first identified by synthetic lethal high-throughput screening by Stockwells group as a small molecule compound efficiently killing human tumor cells without affecting their isogenic normal cell counterparts 19

Yet, it often influences our resilience,

Long exposure to high glucose concentration impairs the responsive expression of -glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells

Onuh JO, Girgih AT, Malomo SA, Aluko RE, Aliani M (2015) Kinetics of in vitro renin and angiotensin converting enzyme inhibition by chicken skin protein hydrolysates and their blood pressure lowering effects in spontaneously hypertensive rats