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Singapore: Bentham Science Publishers (2023)

Aside from these examples, little is known about the biophysical impact of many other sitespecific posttranslational modifications on apoSOD1 stability, despite numerous solventaccessible sites for glutathionylation, acetylation, glycation, phosphorylation, succinylation and ubiquitylation (Figure 9).[ 62 , 72 , 86 , 120b , 124 ] Advances in this area will require greater refinement of emerging methodologies designed to target certain modifications to specific protein residues in vitro and in vivo, [132] including selective chemical modification of proteins, protein semisynthesis, native chemical ligation, and the genetic noncanonical amino acid incorporation approach

Acta Anaesthesiol Taiwanica 51:9496 Takahashi K, Terashima H, Kohno K, Ohkohchi N (2013) A stand-alone synbiotic treatment for the prevention of D-lactic acidosis in short bowel syndrome

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