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These investigations provide insights into the metabolic regulation of contractile adaptation and the cellular mechanisms underlying activity-induced metabolic remodeling in muscle tissue across different experimental conditions

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Rather than merely debating compounding categories, regulatory bodies must recognize that without robust oversight and a strict mandate for high-quality clinical evidence, the widespread adoption of these signaling molecules will continue to outpace our clinical understanding of their long-term safety, effectively turning an entire generation of patients into an unregulated experiment