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[email protected] Li, [email protected] These authors have contributed equally to this work This article was submitted to Cellular and Molecular Mechanisms of Brain-aging, a section of the journal Frontiers in Aging Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Combinations of particular interest include glycolysis + OXPHOS inhibition, glutaminolysis inhibition + ferroptosis induction, and metabolic inhibitors + immunotherapy

TCM herbs such as Salvia miltiorrhiza and Poria cocos modulate inflammation by regulating cytokine production and inhibiting NF-B activation, which leads to reduced inflammation and improved insulin sensitivity