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FN1 rs1250248 is implicated in the angiogenic pathway, WNT4 rs7521902 in embryonic development, GREB1 rs13394619 in the hormonal pathway, VEZT rs10859871 in cytoskeleton regulation [75], and IL1A rs6542095 in various immune responses and inflammatory pathways [76]

The metabolic profiles of gastric tissue could offer a direct description of its pathological process during the onset and progression of CAG, and facilitate the understanding of the underlying mechanism of CAG

Researchers can pharmacologically dissect these pathways using LY294002 (PI3K inhibitor) or U0126 (MEK inhibitor) to determine which downstream arm mediates a specific IGF-1 LR3 effect in their experimental system

Wang W, Zhou H, Liu L