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The original Cell Metabolism discovery paper established that MOTS-c regulates insulin sensitivity through this pathway, and later work in Nature Communications by Reynolds et al

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Despite the widespread use of CPZ, the mechanism by which it induces demyelination and allows spontaneous remyelination without damaging to other types of neural cells in the brain, is still unclear

Geological features such as the presence of chaos regions (Greenberg et al., 1999) and cycloidal ridges (fractures on the ice shell) (Smith et al., 1979) further corroborate the presence of a liquid water ocean and its interaction with the icy surface